Detalhe da pesquisa
1.
Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Nature
; 560(7717): 192-197, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30046105
2.
Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis.
Nature
; 619(7970): E48, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37402863
3.
Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency.
Drug Resist Updat
; 67: 100932, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36706533
4.
Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum.
Nucleic Acids Res
; 47(22): 11574-11588, 2019 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-31728527
5.
Patient-derived gene and protein expression signatures of NGLY1 deficiency.
J Biochem
; 171(2): 187-199, 2022 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34878535
6.
1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis.
ACS Infect Dis
; 8(11): 2315-2326, 2022 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36325756
7.
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages.
Sci Transl Med
; 14(667): eabo7219, 2022 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36260689
8.
The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis.
Sci Transl Med
; 14(643): eaaz6280, 2022 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35507672
9.
The multi-target aspect of an MmpL3 inhibitor: The BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation.
Cell Surf
; 7: 100068, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34888432
10.
Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG.
Sci Adv
; 7(13)2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33762339
11.
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation.
Sci Immunol
; 6(58)2021 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33827897
12.
Loss of N-Glycanase 1 Alters Transcriptional and Translational Regulation in K562 Cell Lines.
G3 (Bethesda)
; 10(5): 1585-1597, 2020 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32265286
13.
CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model.
Sci Transl Med
; 12(541)2020 04 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32350131
14.
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity.
Cell Chem Biol
; 27(7): 806-816.e8, 2020 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32359426
15.
High-throughput screening of the Plasmodium falciparum cGMP-dependent protein kinase identified a thiazole scaffold which kills erythrocytic and sexual stage parasites.
Sci Rep
; 9(1): 7005, 2019 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31065005
16.
Development of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites.
J Med Chem
; 62(20): 9217-9235, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31566384
17.
Identification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis.
J Med Chem
; 62(3): 1180-1202, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30570265
18.
Development of Chemical Proteomics for the Folateome and Analysis of the Kinetoplastid Folateome.
ACS Infect Dis
; 4(10): 1475-1486, 2018 10 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30264983
19.
Drug-perturbation-based stratification of blood cancer.
J Clin Invest
; 128(1): 427-445, 2018 01 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29227286
20.
Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.
J Med Chem
; 60(24): 10118-10134, 2017 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29148755